エマルションによる経皮薬物送達技術の最新研究 – 経皮吸収促進剤とイオン液体の利用を中心に–

小坂 秀斗, 原 江希, 後藤 雅宏
膜, 46, 91-97 (2021).　　

　　

Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug

S. Uddin, M. R. Islam, M. R. Chowdhury, R. Wakabayashi, N. Kamiya, M. Moniruzzaman, M. Goto
ACS Applied Bio Materials, in press (2021).　　

　　

Self-Assembled Palmitoyl-Glycine-Histidine as a Permeation Enhancer for Transdermal Delivery

T. Imoto, M. Goto
Langmuir, 37, 8971-8977 (2021).　　

　　

Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel

M. K. Ali, R. M. Moshikur, R. Wakabayashi, M. Moniruzzaman, M. Goto
ACS Appl. Mater. Interfaces, 13, 19745-19755 (2021).　　

　　

Biocompatible ionic liquids assisted transdermal co-delivery of antigenic protein and adjuvant for cancer immunotherapy

M. R. Chowdhury, R. M. Moshikur, R. Wakabayashi, M. Moniruzzaman, M. Goto
Int. J. Pharm., 601, 120582 (2021).　　

　　

Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide

M. Kitaoka, T. C. Nguyen, M. Goto
Int. J. Cosmet. Sci., in press (2021).　　

　　

Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis

Q. Kong, M. Kitaoka, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Goto
Pharmaceutics, 12(3), 240, (2020).　　

　　

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

M. Sivapragasam, M. Moniruzzaman, M. Goto
Biotechnology Journal, 15, 1900073 (2020).　　

　　

Biocompatible ionic liquids and their application in pharmaceutics

Rahman Md Moshikur, Md. Raihan Chowdhury, Muhammad Moniruzzaman, and Masahiro Goto
Green Chemistry, 22,8116-8139 (2020).　　

　　

Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation

R. M. Moshikur, C. M. Raihan, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Moniruzzaman, M. Goto
Journal of Molecular Liquids, 299, 112166 (2020).　　

　　

Transcutaneous cancer vaccine using a reverse micellar antigen carrier

S. Kozaka, Y. Tahara, R. Wakabayashi, T. Nakata, T. Ueda, N. Kamiya, M. Goto
Molecular Pharmaceutics, 17, 645-655 (2020).　　

　　

A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies

M. Kitaoka, W. Xiao, Q. Kong, Y. Tahara, N. Kamiya, M. Goto
Pharmaceutics, 12(3), 205 (2020).　　

　　

Biocompatible Ionic Liquid Surfactant Based Microemulsion as a Potential Carrier for Sparingly Soluble Drugs

M.K. Ali, R.M. Moshikur, R. Wakabayashi, M. Moniruzzaman, N. Kamiya, M. Goto
ACS Sustainable Chemistry & Engineering, accepted.　　

　　

Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug Acyclovir

I. M. Rafiqul, C. M. Raihan, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Moniruzzaman, M. Goto
International Journal of Pharmatheutics, 582, 119335 (2020).　　

　　

Ionic liquid-in-oil microemulsions prepared with biocompatible choline carboxylic acids for improving the transdermal delivery of a sparingly soluble drug

I. M. Rafiqul, C. M. Raihan, R. Wakabayashi, N. Kamiya, M. Moniruzzaman, M. Goto
Pharmaceutics, 12, 392 (2020).　　

　　

A Novel Binary Supercooled Liquid Formulation for Transdermal Drug Delivery

Y. Hirakawa, H. Ueda, R. Wakabayashi, N. Kamiya, M. Goto
Biological and Pharmaceutical Bulletin, 43, 393-398 (2020).　　

　　

Effective transcutaneous delivery of hyaluronic acid using an easy-to-prepare reverse micelle formulation

S. Kozaka, A. Kashima, T. Nakata, T. Ueda, R. Wakabayashi, M. Goto
Cosmetics, 7(3), 52 (2020).　　

　　

Monoolein Assisted Oil-Based Transdermal Delivery of Powder Vaccine

M. Kitaoka, A. Oka, M. Goto
Pharmaceutics, 12, 814-826(2020).　　

　　

Solid-in-oil nanodispersions as a novel delivery system to improve the oral bioavailability of bisphosphate, risedronate sodium

Y. Hou, H. Piao, Y. Tahara, S. Qin, J. Wang, Q. Kong, M. Zou, G. Cheng, M. Goto
European Journal of Pharmaceutical Sciences, 155, 105521 (2020).　　

　　

Design and Characterization of Fatty Acid Based Amino Acid Ester as a new “Green” Hydrophobic Ionic Liquid for Drug Delivery

R. Md Moshikur, Md. R. Chowdhury, H. Fujisawa, R. Wakabayashi, M. Moniruzzaman, M. Goto
ACS Sustainable Chemistry & Engineering, accepted.　　

　　

Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect

Y. Tahara, K. Morita, R. Wakabayashi, N. Kamiya, M. Goto
Molecular Pharmaceutics, 17, 3845-3856(2020).　　

　　

Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant

R. Md Moshikur, Md. K. Ali, R. Wakabayashi, M. Moniruzzaman, M. Goto
Journal of Molecular Liquids, 320, 114424(2020).　　

　　

Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation

S. Uddin, Md. R. Chowdhury, R. Wakabayashi, N. Kamiya, M. Moniruzzaman, M. Goto
Chem. Comm., 56,13756-13759 (2020).　　

　　

Solid-in-oil-in-water(S/O/W)型多層エマルションとDDSへの応用

田原義朗、後藤雅宏
オレオサイエンス, 19(5), 191-196 (2019).

　　

油状ナノ基剤を用いたDDS技術と非侵襲性経皮ワクチンへの応用

田原義朗、後藤雅宏
化学工学、83(7), 408-411(2019).　　

　　

Ionic Liquids Pretreatment of Lignocellulosic Biomass for Enhanced Enzymatic Delignification

M. Moniruzzaman and M. Goto
Application of Ionic Liquids in Biotechnology, 168, pp.61-77, Springer (2019).

　　

A novel binary supercooled liquid formulation for transdermal drug delivery

Y. Hirakawa, H. Ueda, R. Wakabayashi, N. Kamiya, M. Goto
Biol. Pharm. Bull., 43(3), 393-398 (2019).　　

　　

Transcutaneous delivery of immunomodulating pollen extract-galactomannan conjugate by solid-in-oil nanodispersions for pollinosis immunotherapy

Q. Kong, K. Higasijima, R. Wakabayashi, Y. Tahara, M. Kitaoka, H. Obayashi, Y. Hou, N. Kamiya, M. Goto
Pharmaceutics, 11(11), 563 (2019).　　

　　

Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses

Q. Kong, M. Kitaoka, Y. Tahara, R. Wakabayashi, N. Kamiya, M. Goto
Int. J. Pharm., 572(15), 118777 (2019).　　

　　

New insight into transdermal drug delivery with supersaturated formulation based on co-amorphous system

Y. Hirakawa, H. Ueda, T. Miyano, N. Kamiya and M. Goto
Int. J. Pharm., 569(5), 118582 (2019).　　

　　

Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

C. M. Raihan, R. M. Moshikur, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Moniruzzaman, M. Goto
Chem. Commun., 55, 7737-7740 (2019).　　

　　

Skin Permeation Enhancement of Bioactive Macromolecules by Reverse Micelles

S. Kozaka, T. Nakata, S. Tajima, T. Ueda, M. Goto
MEMBRANE, 44, 130-135 (2019).　　

　　

In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersesnsitivity evaluation of ionic liquid-mediated paclitaxel formulations

C. M. Raihan, R. M. Moshikur, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Moniruzzaman, M. Goto
Int. J. Pharm., 565, 219-226 (2019).　　

　　

Synthesis and characterization of choline-fatty acid-based ionic liquids: A new biocompatible surfactant

Md Korban Ali, R. M. Moshikur, R. Wakabayashi, Y. Tahara, M. Moniruzzaman, N. Kamiya, M. Goto
J. Colloid Interface Sci., 551, 72-80 (2019).　　

　　

Self-assembled reduced albumin and glycol chitosan nanoparticles for Paclitaxel delivery

A.R. Muhamad, R. Wakabayashi, M. Goto, N. Kamiya
Langmuir, 35, 2610-2618 (2019).　　

　　

Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation

R.M. Moshikur, C.M. Raihan, R. Wakabayashi, Y. Tahara, M. Moniruzzaman, M. Goto
J. Mol. Liq., 278, 226-233 (2019).　　

イオン液体の経皮吸収促進効果を利用したドラッグデリバリーシステム

若林里衣、小坂秀斗、後藤雅宏
膜(MEMBRANE), 43(3), pp.108-114, 技術情報協会出版 (2018).

Ionic-liquid-based paclitaxel preparation: A new potential formulation for cancer treatment

C. M. Raihan, R. M. Moshikur, R. Wakabayashi, N. Kamiya, Y. Tahara, M. Moniruzzaman, M. Goto
Mol. Pharm., accepted.

Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids

R. M. Moshikur, C. M. Raihan, R. Wakabayashi, Y. Tahara, M. Moniruzzaman, M. Goto
Int. J. Pharm., 546, 31-38 (2018).

Solid-in-oil peptide nanocarriers for transcutaneous cancer vaccine delivery against melanoma

R. Wakabayashi†, M. Sakuragi†, S. Kozaka, Y. Tahara, N. Kamiya, M. Goto
Mol. Pharm., 15, 955-961 (2018). (†these authors contributed equally)

Solid-in-Oil 技術による経皮吸収促進

後藤雅宏
次世代経皮吸収型製剤の開発と応用, pp.103-111 シーエムシー出版 (2017).

Solid-in-oil technique to increase skin permeation

M. Kitaoka, M. Goto
Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds, pp.205-224, Sprinder（2017).

経皮吸収製剤における最新の経皮吸収技術

田原義朗、後藤雅宏
DDS先端技術の製剤応用, pp.403-409, 技術情報協会出版 (2017).

Ionic liquid based nanocarriers for topical and transdermal drug delivery

M. Moniruzzaman, M. Goto
Smart Materials Series No. 28, RSC book (2017).

Solid-in-Oil (S/O) 技術を利用したタンパク質の経皮デリバリーと経皮ワクチンへの応用

田原義朗、後藤雅宏
Drug Delivery System, 32-3, pp.176-183 (2017).

Transcutaneous immunotherapy of pollinosis using solid-in-oil nanodispersion loaded with T cell epitope peptide8

Q. Kong, M. Kitaoka, R. Wakabayashi, N. Kamiya, M. Goto
Int. J. Pharm., 529, 401-409 (2017).

Transcutaneous pollinosis immunotherapy of using solid-in-oil nanodispersion system carrying T cell epitope peptide and R848

M. Kitaoka, A. Naritomi, Y. Kawabe, M. Kamihira, N. Kamiya, M. Goto
Bioeng. Translational Med., 2, 102-108 (2017).

イオン液体を利用した薬物送達システム

後藤雅宏、荒木祥太、若林里衣
表面技術、第67巻、第2号、pp.84-89 (2016).

「低分子ゲルの開発と応用」13章、超分子ペプチド脂質を用いて形成した超分子ゲルのDDSへの応用

後藤雅宏
pp.152-159, シーエムシー出版 (2016).

Solid-in-oil nanodispersions for transdermal drug delivery systems

M. Kitaoka, R. Wakabayashi, N. Kamiya, M. Goto
Biotechnol. J., 11, DOI 10.1002/biot.201600081 (2016). 'open access'

経皮吸収促進のためのDDS-新規油状可溶化型のナノ粒子-

後藤雅宏
ファルマシア、第52巻、第11号、印刷中 (2016).

Ionic liquids as a potential tool for drug delivery systems

N. Adawiyah, M. Moniruzzaman, S. Hawatulailaa, M. Goto
Med.Chem.Comm., 7, DOI: 10.1039/C6MD00358C, (2016)

Transcutaneous Immunization Using Nano-sized Drug Carriers

M. Kitaoka, M. Goto
Nanomaterials in Pharmacology, Chapter 18, pp.349-368, Humana Press（2016).

Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions

S. Araki, R. Wakabayashi, M. Moniruzzaman, N. Kamiya, M. Goto
Med. Chem. Commun., 6, 2124-2128 (2015).

Transcutaneous peptide immunotherapy of Japanese cedar pollinosis using Solid-in-Oil nanodispersion technology

M. Kitaoka, Y. Shin, N. Kamiya, Y. Kawabe, M. Kamihira, M. Goto
AAPS PharmSciTech, 16, 1418-1424 (2015).

Transcutaneous immunization against cancer using solid-in-oil nanodispersions

Y. Hirakawa, R. Wakabayashi, A. Naritomi, M. Sakuragi, N. Kamiya, M. Goto
Med. Chem. Commun., 6, 1387-1392 (2015).

Transdermal Immunization using Solid-in-oil Nanodispersion with CpG Oligodeoxynucleotide Adjuvants,

M. Kitaoka, A. Naritomi, Y. Hirakawa, N. Kamiya, M. Goto,
Pharm. Res., 32(4), 1486-1492 (2015).

Sucrose laurate-enhanced transcutaneous immunization with a solid-in-oil nanodispersion,

M. Kitaoka, K. Imamura, Y. Hirakawa, Y. Tahara, N. Kamiya, M. Goto,
Med. Chem. Commun., 5 (1), 20-24 (2014). (Front Cover)

Preparation of Multiple Emulsions to Depress the Release of Drugs and Enhanced Permeation Effect in Transdermal Delivery,

Y. Abe, Y. Tahara, R. Wakabayashi, N. Kamiya, M. Goto,
MEMBRANE, 38(2), 92-96(2013). in Japanese

S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity.

T. Okuda, Y. Tahara, N. Kamiya, M. Goto, S. Kidoaki
J. Biomat. Sci.-Polym. E., 24, 1277-90 (2013).

Ionic Liquid-in-Oil Microemulsions as Potential Carrier for the Transdermal Delivery of Methotrexate

H. Yoshiura, M. Tamura, M. Aso, N. Kamiya, M. Goto
J. Chem. Eng. Japan, 46(11), 794-796(2013).

Needle-free immunization using a solid-in-oil nanodispersion enhanced by a skin-permeable oligoarginine peptide

M. Kitaoka, K. Imamura, Y. Hirakawa, Y. Tahara, N. Kamiya, M. Goto
Int. J. Pharm., 458(2), 334-339 (2013).